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CRISPR-Display can reconstitute both natural regulatory ncRNAs and artificial ncRNA devices, and can simultaneously deploy multiple different functions to discrete genomic targets. This enables an extremely broad range of bioengineering, systems-biological, and chemical-biological applications. https://images.squarespace-cdn.com/content/v1/5ec321c2af33de48734cc929/1589847903067-57HDPDJ6TWU40QPAQLS4/image-asset.jpeg CRISPR - Make it stand out. It all begins with an idea. Maybe you want to launch a business. Maybe you want to turn a hobby into something more. Or maybe you have a creative project to share with the world. Whatever it is, the way you tell your story online can make all the difference. https://www.shechnerlab.org/publications-1 daily 0.75 2021-09-11 https://images.squarespace-cdn.com/content/v1/5ce435d6bea1ed00016ba287/1558964652247-5MWXNMFZVOPGE4TY6U2Q/MHeiderich_ReflexionenZwei-05-copy.jpg Dummy Page https://www.shechnerlab.org/research daily 0.75 2023-02-17 https://images.squarespace-cdn.com/content/v1/6137599c70437e718462638b/3ca53e80-b9b8-48f0-a61d-4fb0f4fdc3b1/Architectural_RNA.jpg Research - Make it stand out SheqLab seeks to elucidate the molecular mechanisms by which RNAs scaffold and nucleate subcellular architecture, in health and disease. https://images.squarespace-cdn.com/content/v1/6137599c70437e718462638b/6048f489-5885-43a0-b8f1-4c597b61297d/O-MAP_Thumbnail.jpg Research - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/6137599c70437e718462638b/f87b3ef3-493d-4d79-8c98-227ffacf5c0b/Nuclear_Body_Assmembly.jpg Research - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/6137599c70437e718462638b/cd51f5a4-1821-48dc-b60e-73b0792f6b5a/pre-mRNA_splicing_factory_schematic.jpg Research - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.shechnerlab.org/team-1 daily 0.75 2023-02-06 https://images.squarespace-cdn.com/content/v1/6137599c70437e718462638b/1631026176098-BZ6Y2HN3IQN3ZTVX91TH/g-480x671.jpg News - Jessica Gianopulos Graduate Student, MCB Co-mentored with Sita Kugel Jessica received her undergraduate degree in Molecular, Cellular, and Developmental Biology from the University of Washington. She joined the University of Washington’s MCB program, where she will pursue her interest in cancer research and nuclear architecture. Contact: jessig22@uw.edu https://images.squarespace-cdn.com/content/v1/6137599c70437e718462638b/1631026082394-58RBT90W3ILVQWZ35N71/hsu-480-671.jpg News - Evan Kania Pharmac Chris received his undergraduate degree in Biochemistry from the University of Washington. He joined the Shechner lab in 2018, where he aims to better understand the assembly process of the nucleolus. Contact: chrhsu@uw.edu https://images.squarespace-cdn.com/content/v1/6137599c70437e718462638b/1631026252188-I57E37MPWULDBVRQV5UM/delrosario-671x480.jpg News - Briana Del Rosario Undergraduate Researcher Briana currently working towards her Bachelors in Molecular, Cellular, and Development in Biology. She is currently working on investigating the nucleolus and analyzing the impact of RNA on chromatin states. Contact: brianadr@uw.edu https://images.squarespace-cdn.com/content/v1/6137599c70437e718462638b/1631020447414-R75TKEJRZP394N4XZKQK/shechner-480x671.jpg News - David Shechner Tobias Keene, D.D.S. Hailing from Richmond, Virginia, Dr. Tobias Keene brings a bit of unabashed Southern hospitality to all his patients. He moved to Washington, D.C. over thirty years ago as a freshman at Ivy College. Right after graduation, he attended World University’s School of Dentistry. Before opening Keene Dental in 1994, he worked for free clinics and some of the finest practices in the District. He is part of the 123 Dental Association and stays up-to-date on the latest dental discoveries. When not striving to keep his patients happy and healthy, he’s enjoys hiking with his family in Rock Creek Park. https://images.squarespace-cdn.com/content/v1/6137599c70437e718462638b/1631030136682-CQFLOY3PA9SZ6P1143TF/Ashley+Tsue News - Ashley Tsue Graduate Student, Pharmacology Ashley received her undergraduate degree in Chemistry from Princeton University in 2017. She joined the University of Washington’s Pharmacology Department in 2018, where she will pursue Biochemistry and Molecular Biology. Contact: atsue@uw.edu https://www.shechnerlab.org/publications daily 0.75 2023-02-17 https://images.squarespace-cdn.com/content/v1/6137599c70437e718462638b/994786e0-a544-4b92-a8e0-3433dce0e33b/O-MAP_Thumbnail.jpg Publications - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/6137599c70437e718462638b/2068bc53-104c-400c-8930-8f9cab0d16cc/Shukla_et_al_Thumbnail.jpg Publications - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/6137599c70437e718462638b/e49aea43-2651-46d7-8024-abf3f4eba8dc/pSABER_Thumbnail.jpg Publications - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/6137599c70437e718462638b/6aca647c-4e31-462f-88ee-0ac46ed18b14/Koldobskaya_et_al_Thumb.jpg Publications - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/6137599c70437e718462638b/317474a6-c6c0-4852-92d6-bfdfb1209137/Mele_et_al_Thumb.jpg Publications - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/6137599c70437e718462638b/e8217493-7ac0-4914-8c01-a4f45b4e7ce1/MRFs_Thumbnail.jpg Publications - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/6137599c70437e718462638b/79c6529e-3ed4-4e83-bf06-b3a0eb7ccea4/CRISP-Disp_Thumb.jpg Publications - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/6137599c70437e718462638b/77ceca71-7764-4e82-bb4d-a60b76cb8e26/bagby_thumbnail.jpg Publications - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/6137599c70437e718462638b/d6299492-e7c8-49ea-aeb0-55657f875b87/split_apex_smaller.jpg Publications - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/6137599c70437e718462638b/63713d35-896b-441c-bdaa-0dc5846595c8/Ligase_xtal_Structure.jpg Publications - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/6137599c70437e718462638b/ed841fd9-bbff-4e6e-8784-a84ffa499bb8/Cas9_Swiss_army_Knife.jpeg Publications - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/6137599c70437e718462638b/67c2119a-1446-4c76-b3e5-d680ebc25a83/APEX-RIP_Thumb.jpg Publications - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/6137599c70437e718462638b/efb713ed-d6ac-417a-8e43-daeec44e926a/Shechner_Bartel_2011_Thumb.jpg Publications - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/6137599c70437e718462638b/91ce7ebe-7b75-4361-9645-8978446629bb/SNP-CLING_thumbnail.jpg Publications - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5ce435d6bea1ed00016ba287/1558964652247-5MWXNMFZVOPGE4TY6U2Q/MHeiderich_ReflexionenZwei-05-copy.jpg Publications https://www.shechnerlab.org/joinsheqlab daily 0.75 2023-03-24 https://images.squarespace-cdn.com/content/v1/5ce435d6bea1ed00016ba287/1558964652247-5MWXNMFZVOPGE4TY6U2Q/MHeiderich_ReflexionenZwei-05-copy.jpg Join Us! https://www.shechnerlab.org/labvalues daily 0.75 2023-02-15 https://images.squarespace-cdn.com/content/v1/5ce435d6bea1ed00016ba287/1558964652247-5MWXNMFZVOPGE4TY6U2Q/MHeiderich_ReflexionenZwei-05-copy.jpg Shechner Lab Values https://www.shechnerlab.org/postdoc-ad daily 0.75 2023-03-24 https://images.squarespace-cdn.com/content/v1/6137599c70437e718462638b/448ad8fb-1b6f-414c-bb26-14fc67d3e79c/Postdoc_Ad_Thumb.jpg https://images.squarespace-cdn.com/content/v1/6137599c70437e718462638b/0270dd27-8b73-4fb5-88bb-518f38d0c8a4/2022_Group_Photo.jpg https://images.squarespace-cdn.com/content/v1/6137599c70437e718462638b/6dabaced-b527-4d26-82c5-8453f505c3e6/UW_Cherry_Blossoms.jpg https://www.shechnerlab.org/research-alt daily 0.75 2021-09-11 https://www.shechnerlab.org/research-alt/iisaac monthly 0.5 2021-09-07 https://images.squarespace-cdn.com/content/v1/6137599c70437e718462638b/1631031872123-URHEX1156LD3KO3W5W0A/IISAAC Research (alt) - IISAAC - IISAAC IISAAC (Interactions by In Situ Affinity-tagging And Crosslinking, also called APEX-RIP) is a universal method for mapping the sub-cellular localization of RNA, transcriptome-wide. IISAAC uses in situ proximity-restricted biotinylation to isolate RNAs that reside in or near a target sub-cellular compartment, including structures that are recalcitrant to conventional biochemical fractionation. This approach can be applied in parallel to proteomic, transcriptomic and genomic analyses, allowing us to comprehensively catalog the macromolecular composition (proteins, RNAs, DNA loci) of target sub-cellular regions at unprecedented breadth. https://www.shechnerlab.org/research-alt/cling monthly 0.5 2021-09-07 https://images.squarespace-cdn.com/content/v1/6137599c70437e718462638b/1631031793251-I7XZ6EK1X9ZOXPS54CNO/CLING-01.jpg Research (alt) - CLING - CLING CLING (CRISPR-Display Live-Cell ImagiNG) is a method for visualizing chromatin dynamic in vivo (pictured on the right). CLING exploits the multiplex ability of CRISPR-Display to label endogenous genomic sites with unique fluorophores, allowing the behavior of these loci-their localization, mobility, interactions with other genomic sites and subnuclear structures, etc. — to by observed in real time. https://www.shechnerlab.org/research-alt/crispr-display monthly 0.5 2021-09-07 https://images.squarespace-cdn.com/content/v1/6137599c70437e718462638b/1631031663546-A8GB6LRRLAE38SUXIV2I/CRISPR-Display Research (alt) - CRISPR-Display - CRISPR-Display CRISPR-Display is a versatile method for ectopically localizing ncRNA domains or ribonucleoprotein (RNP) complexes to any genomic locus, where their functions can be scrutinized or utilized (pictured on the left). CRISPR-Display can reconstitute both natural regulatory ncRNAs and artificial ncRNA devices, and can simultaneously deploy multiple different functions to discrete genomic targets. This enables an extremely broad range of bioengineering, systems-biological, and chemical-biological applications.